Endocrine Abstracts

Introduction: Offspring of mothers with diabetes have greater risk of adverse metabolic outcome in later life. Increased adiposity is a plausible mediator. We performed a meta-analysis of studies examining adiposity in infants and children in relation to maternal diabetes.Methods: Citations were identified in PubMed and authors contacted for additional data. Fat free mass, fat mass, body fat %, and skinfold thickness were compared in offspring of mothers...

We have previously shown that premature piglets maintained on TPN develop fatty livers, but the underlying mechanisms associated with this response in unknown. The aim of the experiment was to use a piglet model for the premature human neonate on TPN to investigate lipase activity in key tissues.Piglets were delivered, by Caesarean, two days prematurely. Bilateral jugular catheters were surgically inserted within 6 hours of birth. Six control piglets wer...